Born Nicholas Brendon Schultz, he came into the world three minutes after his twin brother Kelly, on April 12, 1971. Nick originally aspired to be a baseball player, but an injury ended that dream. He decided to try his hand at acting in order to help his stuttering problem and worked many odd jobs while trying to make it, including that of production assistant on the sitcom Dave's Worls. Nick soon landed the role of Xander Harris on Buffy the Vampire Slayer. Based on the 1992 movie of the same name, the show premiered on TheWB on March 10, 1997.
Nick went on to make a few movies, including Pinata and Psycho Beach Party. It was on the set of the former that he met Tressa di Figlia. The two were married, but the union ended in 2006.
In fall of 2005, he joined the cast of Kitchen Confidential, a new sitcom starring Bradley Cooper. Nick played pastry chef Seth, but show was cancelled after four episodes aired. He has also made a pair of movies for ABC Family - Celeste in the City and Relative Chaos.